How is fosamax metabolized?

Preclinically, alendronate is not metabolised in animals and is cleared from the plasma by uptake into bone and elimination via renal excretion. Although soon after administration the drug distributes widely in the body, this transient state is rapidly followed by a nonsaturable redistribution to skeletal tissues.

How is Fosamax absorbed?

If you are using alendronate oral liquid, drink at least 2 ounces (a quarter of a cup) of water immediately after taking the medicine. This will allow the medicine to reach your intestines and be absorbed by the body more quickly. Swallow the tablet whole with a full glass (6 to 8 ounces) of plain water.

Is alendronate metabolized in the liver?

The bisphosphonates are taken up by bone matrix and rapidly cleared from the serum by renal excretion. Hepatic metabolism is minimal, and thus it is somewhat surprising that they can be associated with hepatic injury.

Can Fosamax cause kidney problems?

The results indicate chronic use of alendronate for osteoporosis may impair renal function or increase renal related problems in patients with existing kidney disease.

How is alendronate absorbed?

Alendronate, like all bisphosphonates, is absorbed poorly in animals and humans, oral bioavailability is less than 2% in all species studied, including humans. Systemically available alendronate disappears very rapidly from plasma, and the drug is either taken up by bone tissues or excreted by the kidneys.

Where is alendronate metabolized?

Preclinically, alendronate is not metabolised in animals and is cleared from the plasma by uptake into bone and elimination via renal excretion. Although soon after administration the drug distributes widely in the body, this transient state is rapidly followed by a nonsaturable redistribution to skeletal tissues.

Why was Fosamax taken off the market?

Researchers say that the fractures occurred because alendronate stops the body from breaking down bone. This creates thick, but brittle bones. In October 2010, the FDA ordered Merck to change its drug label to reflect the bone-fracture connection. Fosamax use may also make fractures more difficult to heal.

Can Fosamax elevated liver enzymes?

After the alendronate therapy was discontinued, the patient’s hepatic enzyme levels slowly returned to normal. Hepatotoxicity due to alendronate therapy is a rare but possible adverse effect.

Can I stop alendronate cold turkey?

It may affect the way this medicine works if you do not. Do not stop using this medicine suddenly without asking your doctor.

Who should not take alendronate?

You should not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. Do not take alendronate if you cannot sit upright or stand for at least 30 minutes after taking the medicine. Alendronate can cause serious problems in the stomach or esophagus.

Should I take calcium with Fosamax?

Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood, while you take FOSAMAX PLUS D. Take calcium and vitamin D as your doctor tells you to.

Is risedronate hard on the kidneys?

Risedronate had minimal to no adverse effects on kidney function. Renal-transplant patients receiving long-term glucocorticoid treatment are at greater risk for bone deterioration because of pre-existing renal dysfunction.

Does alendronic acid affect kidneys?

have low calcium levels in your blood – alendronic acid sometimes causes low blood calcium, so your calcium levels could become even lower. have kidney problems.

Can you take vitamin D with alendronate?

Alendronate with either 2,800 IU or 5,600 IU of vitamin D3 provides another option for a source of vitamin D. Weekly alendronate with 2,800 IU of vitamin D3 is the equivalent of taking 400 IU daily, while weekly alendronate with 5,600 IU of vitamin D3 is the equivalent of taking 800 IU daily.

Where is Fosamax absorbed by the body?

Our data suggest that in patients with Crohn’s disease, alendronate is adequately absorbed from the intestine and retained in the skeleton. This adequacy is confirmed by appropriate suppression of bone resorption and increase in lumbar spine BMD.

Why do you have to take alendronate on an empty stomach?

The drugs must be given on an empty stomach because food and beverages interfere with gastrointestinal absorption. Of the absorbed fraction, as much as 60% is taken up by the skeleton and the remainder is excreted unchanged in the urine.

Is Fosamax IV or oral?

How Should Fosamax Be Taken? Fosamax is available in a tablet or oral liquid form. Each bottle of the oral solution contains 91.35 mg of alendronate monosodium salt trihydrate, which is the molar equivalent to 70 mg of the drug.

Is there an alternative to Fosamax?

Boniva is the brand name for the generic drug ibandronate. Like Fosamax, Boniva is also a bisphosphonate. It is FDA-approved to prevent and treat postmenopausal osteoporosis.

Why is Fosamax taken once a week?

How does FOSAMAX Once Weekly work? FOSAMAX Once Weekly works by slowing down the process of old bone being removed, which allows the bone-forming cells time to rebuild normal bone. FOSAMAX Once Weekly not only helps prevent the loss of bone but actually helps to rebuild bone and makes bone less likely to fracture.

Does Fosamax increase bone density?

Fosamax and other drugs such as Actonel, Boniva, and Reclast increase bone density and help prevent and treat osteoporosis and/or reduce the risk of fractures.

Can you have a tooth pulled while on Fosamax?

Jan. 2, 2009 — After having teeth pulled, 4% of patients in a study who were taking Fosamax developed a dangerous condition called osteonecrosis of the jaw, USC researchers report. None of the tooth extraction patients not taking Fosamax developed osteonecrosis.

Is Fosamax worth taking?

The study showed that the drug Fosamax was effective in maintaining bone mineral density at the spine for 10 years, regardless of the age of the patients or the extent of bone loss at the start of treatment.

How long does it take for alendronate to get out of your system?

After a 2-h intravenous infusion, plasma concentrations of alendronate decline rapidly to approximately 5% of initial values within 6 h. About 50% of a systemic dose is excreted unchanged in the urine in the 72 h following administration.

Should you take a break from Fosamax?

Before stopping Fosamax or any medication, it is important to consult your doctor. Based upon your medical history and individual health risks, your doctor may suggest taking a break. If you do decide to stop taking Fosamax, doctors recommend having regular bone density tests to monitor your status.

How long do you have to be off Fosamax before tooth extraction?

These studies also suggest that stopping a bisphosphonate for 3 months prior to a procedure seems to reduce the incidence of osteonecrosis.

Can you drink coffee after taking Fosamax?

Don’t take Fosamax with coffee, juice, mineral water, soda, or juice. Be sure to take it at least 30 minutes before you eat, drink anything besides plain water, or take any other medications. Taking Fosamax at the same time as food, drinks, or other medications can prevent your body from properly absorbing the drug.

Can I skip a week of Fosamax?

If you miss a dose of once-weekly alendronate, do not take it later in the day. Take the missed dose the following morning and resume your regular dosing schedule the following week. Be sure not to double dose, as this can lead to serious side effects.

Does Fosamax cause hair loss?

Dr. Roach: I found many case reports of hair loss after the use of alendronate (Fosamax) and similar drugs (a class called bisphosphonates).

What is the difference between Fosamax and alendronate?

What is Alendronate (Fosamax®)? Alendronate is commonly known by the brand name Fosamax®. Fosamax® is a bisphosphonate and is used in the treatment of osteoporosis. Fosamax® decreases the rate bone cells are absorbed.

What drugs interact with Fosamax?

Drug interactions of Fosamax include calcium supplements and antacids, intravenous ranitidine, and aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Fosamax has not been studied in pregnant women. It is unknown if Fosamax is secreted in human milk. Consult your doctor before breastfeeding.

What is the new drug for osteoporosis?

Romosozumab (Evenity).

This is the newest bone-building medication to treat osteoporosis. It is given as an injection every month at your doctor’s office and is limited to one year of treatment.

Can I take vitamin D with Fosamax?

Interactions between your drugs

No interactions were found between Fosamax and Vitamin D3. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take magnesium with Fosamax?

Tiludronate and Alendronate — Magnesium may interfere with absorption of medications used in osteoporosis, including alendronate (Fosamax).

Is there an alternative to taking alendronic acid?

The oral bisphosphonates alendronic acid or risedronate sodium are first-line treatment options. Zoledronic acid, denosumab or teriparatide are alternative options in patients intolerant of oral bisphosphonates or in whom they are unsuitable.

Can Fosamax cause kidney stones?

By inhibiting bone breakdown, bisphosphonates help preserve bone mass. And because they contain no calcium or other stone precursors, these drugs have no known connection to formation of kidney stones. Fosamax is not without side effects, however.

Which is better alendronate or risedronate?

Alendronate has been shown to be more effective than risedronate at increasing BMD and reducing bone turnover without increasing the risk for side effects.

How do you treat osteoporosis without medication?

Treatments for established osteoporosis may include exercise, vitamin and mineral supplements, and medications. Exercise and supplementation are often suggested to help you prevent osteoporosis. Weight-bearing, resistance and balance exercises are all important.

Can you take omeprazole with Fosamax?

Interactions between your drugs

No interactions were found between Fosamax and omeprazole. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.

What is the most commonly prescribed drug for osteoporosis?

Bisphosphonates: Most Commonly Prescribed For Osteoporosis

  • Alendronate (Fosamax, Binosto): may be taken orally daily or a weekly tablet is also available.
  • Ibandronate (Boniva): can be taken orally monthly or given by intravenous injection every three months.

What is the best treatment for osteoporosis of the spine?

Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.

What vitamins should not be taken with Fosamax?

multivitamins with minerals alendronate

Alendronate and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of alendronate into the bloodstream and reduce its effectiveness.

How much vitamin D should you take with Fosamax?

The recommended dosage is one 70 mg alendronate/2800 international units vitamin D3 or one 70 mg alendronate/5600 international units vitamin D3 tablet once weekly.

Should you take calcium with alendronate?

It is important that you eat a well-balanced diet with adequate amounts of calcium and vitamin D (found in milk or other dairy products). However, do not take any foods, beverages, or calcium supplements within 30 minutes or longer after taking the alendronate. To do so may keep this medicine from working properly.

Where is alendronate metabolized?

Preclinically, alendronate is not metabolised in animals and is cleared from the plasma by uptake into bone and elimination via renal excretion. Although soon after administration the drug distributes widely in the body, this transient state is rapidly followed by a nonsaturable redistribution to skeletal tissues.

Is alendronate metabolized in the liver?

The bisphosphonates are taken up by bone matrix and rapidly cleared from the serum by renal excretion. Hepatic metabolism is minimal, and thus it is somewhat surprising that they can be associated with hepatic injury.

Can osteoporosis be reversed without Fosamax?

Can osteoporosis be reversed without medications? Your doctor diagnoses osteoporosis based on bone density loss. You can have different degrees of the condition, and catching it early can help you prevent the condition from worsening. You cannot reverse bone loss on your own.

Why was Fosamax taken off the market?

Researchers say that the fractures occurred because alendronate stops the body from breaking down bone. This creates thick, but brittle bones. In October 2010, the FDA ordered Merck to change its drug label to reflect the bone-fracture connection. Fosamax use may also make fractures more difficult to heal.

Does Fosamax cause fatigue?

Alendronate oral tablet doesn’t cause drowsiness but it can cause other side effects.

How long do you have to wait to eat after taking Fosamax?

Wait for at least 30 minutes after taking FOSAMAX to eat, drink, or take other medicines or supplements. Do not lie down for at least 30 minutes after taking FOSAMAX. Do not lie down until after your first food of the day.